Texts:

• Collett, D. (2003) Modelling Survival Data in Medical Research. 2nd ed. Chapman & Hall: London.
• Allison, P.D. (1995) Survival Analysis using the SAS System. SAS: Cary.

Supplemental Texts:

• Collett, D. (1991) Modeling Binary Data. Chapman & Hall: London.
• Hosmer, D.W. and Lemeshow, S. (1989) Applied Logistic Regression. Wiley: NY.
• Morgan, B.J.T. (1992) Analysis of Quantal Response Data. Chapman & Hall: London.
• Lee, E.T. (1992) Statistical Methods for Survival Data Analysis. 2nd ed. Wiley: New York.
• Piegorsch, W.W. and Bailer, A.J. (1997) Statistics for Environmental Biology and Toxicology. Chapman & Hall: London.
  

* Articles and other supplemental material may be placed on Blackboard.

Grading:

Straight 90-80-70-60 split for A,B,C,D, respect. Pluses and Minuses will be used for the border of these intervals.

item contribution to letter grade

Exam 1	20%
Exam 2	20%
Homework	20%
Presentations	10%
Final	30%

Grading comments:

1. Final exam will be CUMULATIVE.

Presentation comments:

On each Thursday throughout the semester, students will present a 10-15 minute summary of a statistical research papers from the biostatistics/biomedical literature. Your contribution, as both presenter and as a discussant, will contribute to your course grade.

Final Schedule: Friday, May xx, hh:mm a.m.

Attendance Policy:

Do not miss class. Lecture and classroom activities are intended to complement the text and out-of-class activities.

Exam Make-up Policy:

There will be NO make-up exams. If you miss an exam during the semester, then the contribution of this grade to your final grade will be transferred to the Final exam. For example, if you miss Exam 1, then your final exam will now contribute 50% to your course grade.

Dates of interest:

Sept. 1	LABOR DAY, no classes
Sept. 2	Monday/Tuesday class exchange day (Monday classes meet).
Sept. 16	Last day to drop a class without a grade (W).
Oct. 7	Last day to drop a course with a grade of W
Oct. 10	Mid-term break, no classes
Nov. 26-28	Thanksgiving break
Dec. 12	Last day of classes

Topic*

Survival distributions and hazard functions [L 1,2,3; A 1,2; C 1]

Nonparametric survival curve estimation

• product limit/Kaplan-Meier estimatest [L 4; A 3; C 2.1.2-2.1.4]
• life-table [L 4; C 2.1.1]
• quantiles; standard errors
  

Nonparametric tests of the equality of survival distributions [L 5; C 2.5-2.8]

• Logrank test
• Mantel-Haenszel test
  

Commonly-used survival distributions [L 6, 7.4; ]

• Exponential
• Weibull
• Lognormal
• Gamma

Parametric tests of the equality of survival distributions [L 9; C 4.4-4.6]

Parametric regression models [A 4; C 4, 6]

• Weibull, log-logistic, accelerated failure time model
• model checking [C 5]

Proportional hazards models [L 10.2; A 5; C 3, 7]

Additional topics selected from:

• Interval censoring [C 8]
• Sample size requirements [C 9]
• Analysis of Epidemiology studies
• Competing risks models [A 9]
• Analyzing Carcinogenicity studies
• Dose-response models
• Risk estimation models
• Methods for Clinical Trials [L 12-13]

Footnote

• L = Lee; A = Allison; C = Collett