Texts:

• Collett, D. (2003) Modelling Survival Data in Medical Research. 2nd ed. Chapman & Hall: London.(DATASETS from Collett)
• Allison, P.D. (1995) Survival Analysis using the SAS System. SAS: Cary.

Supplemental Texts:

• Collett, D. (1991) Modeling Binary Data. Chapman & Hall: London.
• Hosmer, D.W. and Lemeshow, S. (1989) Applied Logistic Regression. Wiley: NY.
• Morgan, B.J.T. (1992) Analysis of Quantal Response Data. Chapman & Hall: London.
• Lee, E.T. (1992) Statistical Methods for Survival Data Analysis. 2nd ed. Wiley: New York.
• Piegorsch, W.W. and Bailer, A.J. (1997) Statistics for Environmental Biology and Toxicology. Chapman & Hall: London.
  

* Articles and other supplemental material may be placed on Blackboard.

Grading:

Straight 90-80-70-60 split for A,B,C,D, respect. Pluses and Minuses will be used for the border of these intervals.

Item	Contribution to grade
Midterm Exam	25%
Homework	25%
Presentations/participation	15%
Final Exam	35%

Grading comments:

1. Final exam will be CUMULATIVE.

Participation/Presentation comments:

On each Thursday throughout the semester, students will take turns leading a 10-15 (+/-) minute discussion of research papers from the biostatistics/biomedical literature. Your contribution, as both presenter and as a discussant, will contribute to your course grade. This will be evaluated weekly on a 0 (not engaged , absent, etc.) - 4 (active contributor tot the discussion) scale.

Final Schedule: Wednesday, May 2, 5:30 p.m. (we can discuss alternate arrangements during class)

Attendance Policy:

Do not miss class. Lecture and classroom activities are intended to complement the text and out-of-class activities.

Dates of interest:

Jan. 11	NRC mtg. (DC) , no class - RESCHEDULE
Jan. 15	Martin Luther King Day , no classes
Jan. 29	Last day to drop without a grade
Feb. 19	President's Day , no classes
Feb. 20	Monday/Tuesday class exchange day (Monday classes meet).
Feb. 27	NRC mtg. (DC) , no class - RESCHEDULE
Mar. 9	Last day to withdraw from a course.
March 11-18	Spring break, no classes (ENAR)
Apr. 17	NRC mtg. (DC) , no class - RESCHEDULE
April 26	Last day of classes

NOTE: We need to reschedule 3 dates because of professional obligations. We need to identify some alternative times when we can meet.

Topic*

Why separate course for survival data? [C 1.1-1.2]

Review of estimation and testing concepts (e.g. likelikihood construction, MLE, LR tests, delta method, etc.) [C Appendix A and B]

Survival distributions and hazard functions [C 1.3]

Nonparametric survival curve estimation [C 2.1-2.4]

• product limit/Kaplan-Meier estimates
• life-table
• quantiles; standard errors
  

Nonparametric tests of the equality of survival distributions [C 2.5-2.9]

• Logrank test
• Mantel-Haenszel test
  

Proportional hazards models [C 3-5]

Parametric tests of the equality of survival distributions [C 6.1-6.3]

Parametric regression models for survival data [C 6.4-6.8, C 7]

• Weibull, log-logistic, accelerated failure time model
• model checking

Additional topics selected from:

• Time-dependent covariates [C 8]
• Interval censoring [C 9]
• Sample size requirements [C 10]
• Analysis of Epidemiology studies
• Competing risks models
• Analyzing Carcinogenicity studies
• Dose-response models
• Risk estimation models
• Methods for Clinical Trials

Footnote

• C = Collett

Joining professional societies as students ...

ENAR (Int'l Biometrics Society) - $27

American Statistical Association - $25