Thermogenesis         

Modo Picture
Previous work has focused on skeletal muscle thermogenesis and the ability of cold acclimation to drive muscle oxidative capacity.  We found that when animals (goats, short-tailed oppossum) were chronically cold exposed that not only were oxidative structures increased, but the enhanced oxidative capacity was available for locomotion, such that cold acclimated animals have greater running VO2max.  Additionally, nearly every characteristic typical of a slow-type muscle is increased to a greater magnitude by cold exposure than by endurance exercise training.


We have begun studies of the impact of cold acclimation on skeletal muscle mitochondrial function using mice lacking brown adipose tissue (UCP-dta).