Work at Miami University

2011

11. Aiguo Liu; Yan Liu; Li Lin; Zhenghu Xu; Hong Wang; Chenglong Li; Jiayuh Li, "XZH-5 Inhibits STAT3 Phosphorylation and Enhances the Cytotoxicity of Chemotherapeutic Drugs in Human Breast and Pancreatic Cancer Cells" submitted to PLoS ONE.
10. Zhenghu Xu, Hong Wang, "Asymmetric Inverse-Electron-Demand Hetero-Diels-Alder Reaction of Ketones", invited SYNPACT paper, accepted to Synlett.
9. L. Jiang, J. T. Engle, L. Sirk, C. S. Hartley, C. J. Ziegler, and H. Wang*, "Triphenylene-fused Porphyrins", Org. Lett., 2011, 13, 3020-3023.
8. A. Liu, Y. Liu, Z. Xu, W. Yu, H. Wang, C. Li, J. Lin, "A Novel Small Molecule, XZH-5, Inhibits Constitutive and Interleukin-6-Induced STAT3 Phosphorylation in Human Rhabdomyosarcoma Cells", Cancer Science, 2011, 102, 1381-1387 Highlighted in Cancer Science.vol.102  iss.7.
7. Y. Liu, A. Liu, Z. Xu, W. Yu, H. Wang, C. Li, J. Lin, "XZH-5 Inhibits STAT3 Phosphorylation and Causes Apoptosis in Human Hepatocellular Carcinoma Cells", Apoptosis, 2011, 16, 502-510.
6. Z. Hu, K. Wheeler, H. Wang*, "Asymmetric Inverse-Electron-Demand Hetero-Diels-Alder Reaction of Cyclic Ketones: An Enamine-Metal Lewis Acid Bifunctional Approach", Angew. Chem. Int. Ed. 2011, 50, 3484-3488. Chosen as a "Hot Paper" by the Editors for its importance in a rapidly evovling field of high current interest. Highlighted in SYNFACTS issue 07/11.
5. P. Daka, Z. Xu, A. Alexa, H. Wang*, " Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: direct asymmetric aldol reaction", Chem. Commun. 2011,47, 224-226. invited paper, issue of Emerging New Investigator. Higlighted in SYNFACT, issue 4/10/2011.

2010

4. Z. Xu, T. Buechler, H. Wang “A Three-Component Reaction Based on Remote Group Directed Dynamic Kinetic Aza Michael Addition: Highly Stereoselective Synthesis of Cyclic Aminals”, Chem. Eur. J. 2010,16, 2972-2976.

2009

3. Z. Xu, P.Daka, H. Wang, "Primary Amine-Metal Lewis Acid Bifunctional Catalysis: the Application to Asymmetric Direct Aldol Reaction" Chem. Commun 2009,6825-6827. Highlighted in SYNFACTS, issue 01/10, 2010.
2. Z. Xu, P. Daka, I. Budik, F. Bai, H. Zhang, H. Wang, "Enamine-Metal Lewis Acid Bifunctional Catalysis: Application to Direct Asymmetric Aldol Condensation", Eur. J. Org. Chem. 2009, 4555-4560. Cover page.
1. R. Deshpande, L. Jiang, G. Schmidt, J. Rokavan, X. Wang, K. Wheeler, H. Wang, "A Concise Synthetic Approach to Opp-dibenzoporphyrins Via the Heck Reaction", Org. Lett. 2009, 4251-4253. Highlighted in SYNFACTS, issue 12/10, 2009.

Patent

1. Jiayuh Lin, Hong Wang, Chenglong Li “XZH-5 INHIBITS CONSTITUTIVE AND INTERLEUKIN-6-INDUCED STAT3 PHOSPHORYLATION IN HUMAN HEPATOCELLULAR CARCINOMA CELLS”, Prov’l Appln Ser. No. 61/421,341, filed December 9, 2010. MST File No.: 1-52502